In July 1762,Catherine the Greatousted her husband , Peter III , as emperor moth of Russia and filled the imperial vacancy herself . A little over six years later , she undertook some extra hazardous clientele : convey vaccinatedagainst variola major .

Catherine had hear firsthand the horrors of the disease , and wished to protect herself , her loved ones , and her subjects from it . So when it was recommend that she have her son inoculated — a procedure that would involve cutting exposed his branch and directly interpose matter from an septic somebody ’s smallpox pustule — Catherine decided to take the saltation first .

“ I used to answer that it would be shameful not to start with myself , and how could I insert smallpox inoculation without prepare a personal example ? ” she write to Prussia ’s King Frederick the Great . “ Should I remain in substantial danger , together with thousands of people , throughout my living , or should I opt a lesser danger , a very brief one , and so economise many people ? ”

Catherine the Great (at getting vaccinated).

Smallpox vaccination , bed asvariolation , was n’t foolproof : Some people did exit after failing to oppose off the sickness . And while India and China had hug inoculation centuries earlier , according toThe New York Times , many Europeans were still exceptionally disbelieving about it . But Catherine knew that the pros of widespread vaccination outweighed the cons — and the chances of dying from variolation were much slender than the chances of dying from variola major itself . In the fall of 1768 , she enlisted an English physician cite Thomas Dimsdale to inoculate her and her son , the next Paul I. Both recover , and Dimsdale soon administer the treatment to other luxuriously - ranking nobles .

Though Catherine ’s successful experience did n’t exactly give way to a nationwide embrace of thevaccine , she did n’t stop trying . On April 20 , 1787 — virtually 20 old age later on — she pen a letter to Count Piotr Aleksandrovich Rumiantsev , who preside over parts of what ’s now Ukraine , asking that he spearhead a vaccine rollout in his region .

“ Such vaccination should be vernacular everywhere , and it is now all the more commodious , since there are Dr. or medical attendants in nearly all districts , and it does not call for immense expenditure , ” she wrote , translated from Russian .

Catherine then went on to detail how it should be done , directing the enumeration to reconstruct “ lodgings for the temporary stay of those who are unable to have this inoculation done at home ” and increase the salary of a certain Doctor of the Church suit to the job .

As a historical phonograph record , the letter reveals just how wholeheartedly the onwards - thinking ruler supported vaccination and what specific touchstone she took to extend the pattern across Russia . As a physical artifact — bearing Catherine ’s tidy script and touch — it ’s worth a lot . AsThe New York Timesreports , the missive , along with a portrayal of Catherine paint by Dmitry Levitsky , just fetched $ 1.3 million at an auction give by London fine nontextual matter auction sign of the zodiac MacDougall ’s .

Catherine the Great was n’t the only famous leader to endorse the variola major vaccinum before her body politic caught on . During his Revolutionary War days , George Washington did , too .

[ h / tThe New York Times ]