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Scientists have harnessedCRISPR gene - redaction technologyto block the replication of the novel coronavirus in human cubicle — an access that could one day help as a new treatment for COVID-19 .
However , the study was performed in science lab dishes and has not yet been tested on animals or people , meaning a treatment ground on the method acting could be year away .
Gene drives replace a natural gene with a new gene, which then gets passed on from generation to generation.
CRISPR is a tool that enables researcher to precisely editDNA . It ’s based on a natural defense system used in bacteria that earmark the microbes to direct and destroy the transmitted fabric ofviruses , Live Science antecedently report .
In the new study , published Tuesday ( July 13 ) in the journalNature Communications , the researchers used a CRISPR system that place and destroys fibril ofRNA , rather than DNA . Specifically , their organization expend an enzyme call Cas13b , which cleaves single strands of RNA , like those found in SARS - CoV-2 , the computer virus that causes COVID-19 . ( Cas13b is similar to Cas9 , the enzyme most unremarkably used in CRISPR gene - editing technology , but Cas9 cleaves DNA while Cas13b cleaves RNA . )
The researcher designed CRISPR - Cas13b to target specific sites on the RNA of SARS - CoV-2 ; once the enzyme bind to the RNA , it destroys the part of the computer virus needed to replicate , according to astatementfrom the Peter MacCallum Cancer Centre in Victoria , Australia , which get together on the research .
" Once the virus is recognized , the CRISPR enzyme is activated and chop up the virus , " study lead author Dr. Sharon Lewin , of the Peter Doherty Institute for Infection and Immunity at the University of Melbourne , toldAFP .
Related:10 astonishing thing scientists just did with CRISPR
The investigator also determine that their method work even when new genetic mutation were introduced into the SARS - CoV-2 genome , including those seen in the alphacoronavirus variant , first discovered in the United Kingdom .
EffectiveCOVID-19 vaccinesare currently being parcel out around the Earth , but there remains a " clear and urgent pauperism " for effective treatments for the disease , the authors said . They noted that there are " serious business organization " that the virus will evolve to " scarper " current vaccines .
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An ideal treatment would be an antiviral drug that patients take shortly after being diagnosed with COVID-19 . " This attack — run and treat — would only be executable if we have a cheap , oral and non - toxic antiviral . That ’s what we hope to achieve one solar day with this gene pair of scissors approach , " Lewin narrate AFP .
Although the new study is a first stone’s throw toward such a treatment , it will probably be years before this method could be turn into a intervention that ’s widely available , AFP reported . The investigator now contrive to test the method in animate being models , and finally conduct clinical trial run in mass .
Medicines that apply CRISPR engineering have not yet been approved to address any disease , but multiple discipline are afoot to quiz CRISPR - ground therapies in citizenry as a handling for various diseases , includingcancerandHIV .
Originally published on Live Science .
